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Ships from: Amazon Sold by: Biotulin USA
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BIOTULIN - Supreme Skin Gel | Reduces Wrinkles Within 1 Hour | Hyaluronic Acid Serum | Spilanthol Serum for Face I Anti Aging Treatment - 0.5 oz
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Return this item for free
We offer easy, convenient returns with at least one free return option: no shipping charges. All returns must comply with our returns policy.
Learn more about free returns.- Go to your orders and start the return
- Select your preferred free shipping option
- Drop off and leave!
Purchase options and add-ons
Skin Type | All |
Product Benefits | Wrinkle Treatment,Anti-Aging |
Use for | Skin |
Scent | fragrance free |
Special Ingredients | hyaluronic_acid |
About this item
- NATURAL ALTERNATIVE TO INJECTIONS: Every day, the skin responds to stress with countless micro-contractions that cause fine lines and wrinkles. Thanks to the combination of complementary ingredients and innovative formulation techniques, Biotulin's Supreme Skin Gel is the first natural and non-invasive alternative to injections for reducing wrinkles and plumping the skin.
- FREEZE THE TIME: Similar to botulinum toxin, Spilanthol is a natural anesthetic derived from Acmella Oleracea that gently and naturally targets the neuromuscular mechanisms of the skin. Combined with plant extracts, this active ingredient with relaxing effects inhibits the micro-contractions of the skin responsible for wrinkles. The muscles are relaxed without being paralyzed, allowing the skin to soften while maintaining its expressiveness and elasticity. In less than an hour, fine lines and wrinkles fade away.
- LONG-LASTING SKIN HYDRATION: The combination of Hyaluronic Acid and Imperata cylindrica provides intense, long-lasting hydration for up to 24 hours.
- CLINICALLY PROVEN RESULTS: Supreme Skin Gel corrects skin imperfections and provides a natural glow for an instantly smoother and younger appearance. Conducted by an esteemed independent German dermatology institute renowned for its cosmetic research, studies have demonstrated a 25% reduction in wrinkles within 8 hours of the first application, with further reduction observed after 20 days of use.
- RESPECTFUL FORMULATION: The result of German cosmetic research, Supreme Skin Gel has a fluid texture that provides a refreshing sensation and is suitable for all skin types. Free of sulfates, parabens, fragrances, silicones, GMOs, and not tested on animals, its formulation is entirely vegan and respectful of your health.
Frequently bought together
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Related Climate Pledge Friendly items
- Sustainability features for this product
Sustainability features
This product has sustainability features recognized by trusted certifications.Safer chemicalsMade with chemicals safer for human health and the environment.As certified byNatrue
Natrue helps consumers identify cosmetic products made from naturally sourced ingredients. Founded in 2007, Natrue is an international non-profit association committed to promoting Natural and Organic cosmetics made with non-genetically modified natural and derived-natural substances. Natrue develops and promotes rigorous criteria for the cosmetics certified with the Natrue Label.Certification LevelNATURAL COSMETICS - Sustainability features for this product
Sustainability features
This product has sustainability features recognized by trusted certifications.Manufacturing practicesThe leather in this product was produced by a Leather Working Group (LWG) certified tannery, supporting more-responsible leather production. LWG brand members may make on-product claims if they have submitted a sourcing declaration and if the product contains >50% leather, and 100% of the leather is produced by a LWG certified tannery.As certified byLeather Working Group
Leather Working Group (LWG) is a not-for-profit community organization dedicated to driving excellence in the production of more-sustainable leather. LWG aims to have a positive impact on the environment through driving resource efficiency in leather production, reduced waste generation and emissions, better chemical management and increased traceability. LWG brand members may make claims on meeting a number of criteria, including submitting a sourcing declaration stating the percentage of leather purchased from LWG certified facilities. A claim can only be made when a product contains leather as the prominent material and 100% of the leather was produced by a LWG-certified tannery. - Sustainability features for this product
Sustainability features
This product has sustainability features recognized by trusted certifications.Safer chemicalsMade with chemicals safer for human health and the environment.As certified byNatrue
Natrue helps consumers identify cosmetic products made from naturally sourced ingredients. Founded in 2007, Natrue is an international non-profit association committed to promoting Natural and Organic cosmetics made with non-genetically modified natural and derived-natural substances. Natrue develops and promotes rigorous criteria for the cosmetics certified with the Natrue Label.Certification LevelNATURAL COSMETICS - Sustainability features for this product
Sustainability features
This product has sustainability features recognized by trusted certifications.Packaging efficiencyReduced air and/or water in the product or packaging for more efficient transportation.As certified byCompact by Design (Amazon-developed Certification)
Compact by Design identifies products that, while they may not always look very different, have a more efficient design. By reducing water and/or air in the product or packaging, these become more efficient to ship. At scale, these small differences in product size and weight lead to significant carbon emission reductions. - Sustainability features for this product
Sustainability features
This product has sustainability features recognized by trusted certifications.Carbon impactCarbon emissions from the lifecycle of this product were measured, reduced and offset.As certified byClimatePartner certified
The Climate neutral label by ClimatePartner certifies that the carbon footprint of a product was calculated and all associated emissions were offset. Additionally, ClimatePartner encourages companies to set ambitious reduction targets and reduce their products' carbon footprints. The certificate number can be entered on ClimatePartner’s website for additional information such as the supported carbon offset project(s). ClimatePartner is improving lives by helping companies tackle climate change with practical solutions.Certification NumberXFL4DW - Sustainability features for this product
Sustainability features
This product has sustainability features recognized by trusted certifications.Carbon impactCarbon emissions from the lifecycle of this product were measured, reduced and offset.As certified byClimatePartner certified
The Climate neutral label by ClimatePartner certifies that the carbon footprint of a product was calculated and all associated emissions were offset. Additionally, ClimatePartner encourages companies to set ambitious reduction targets and reduce their products' carbon footprints. The certificate number can be entered on ClimatePartner’s website for additional information such as the supported carbon offset project(s). ClimatePartner is improving lives by helping companies tackle climate change with practical solutions.Certification Number3YLLHK
From the brand

Biotulin
The natural alternative to injections that effectively reduces fine lines and wrinkles in just 60 minutes.
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Elevate your skincare routine
A plant-based formula with Spilanthol, an ingredient that naturally relaxes facial muscles without freezing your expression.
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An anti-wrinkle for stars born in Germany
Biotulin offers a natural alternative to injections, visibly reducing fine lines and wrinkles in just 60 minutes while keeping your skin deeply hydrated. Powered by Spilanthol, a plant-based anesthetic from paracress, this innovative formula gently targets the skin's neuromuscular mechanisms for a smoother, more youthful complexion—naturally.
Product Description

Compare Biotulin's products
![]() Biotulin Supreme Skin Gel | ![]() Soft Cream | ![]() Eyematrix | ![]() Cream Lace | ![]() Mask | |
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Customer Reviews
|
3.8 out of 5 stars 2,814
|
4.0 out of 5 stars 201
|
3.9 out of 5 stars 166
|
5.0 out of 5 stars 3
|
4.2 out of 5 stars 8
|
Price
| $49.00$49.00 | $49.00$49.00 | $39.00$39.00 | $22.00$22.00 | $13.00$13.00 |
Product type
| Serum | Soft Cream | Cream | Cream | Face Mask |
Area of application
| Face | Face | Around the eyes | Neck & decolleté | Face |
Key Benefits
| Instant wrinkle reduction | Wrinkle reduction + hydration | Anti eye bags | Smoother decolleté | Deep moisturizing |
When to use
| Before applying cream | After applying serum | Before applying face cream | At any time | Before bed |
Not tested on animals
| ✔ | ✔ | ✔ | ✔ | ✔ |
Vegan
| ✔ | ✔ | ✔ | ✔ | ✘ |
Product details
- Is Discontinued By Manufacturer : No
- Product Dimensions : 1.57 x 3.54 x 1.57 inches; 0.71 ounces
- Item model number : BIO0001
- UPC : 731717814948 769675092764 635111765649
- ASIN : B00TOGEGCY
- Country of Origin : Germany
- Best Sellers Rank: #31,057 in Beauty & Personal Care (See Top 100 in Beauty & Personal Care)
- #645 in Facial Serums
- Customer Reviews:
Compare with similar items
This Item ![]() BIOTULIN - Supreme Skin Gel | Reduces Wrinkles Within 1 Hour | Hyaluronic Acid Serum | Spilanthol Serum for Face I Anti Aging Treatment - 0.5 oz | Recommendations | |||||
Try again! Added to Cart | Try again! Added to Cart | Try again! Added to Cart | Try again! Added to Cart | Try again! Added to Cart | Try again! Added to Cart | |
Price | $49.00$49.00 | $29.90$29.90 | $26.00$26.00 | $28.95$28.95 | -30% $23.10$23.10 List: $33.00 | $59.00$59.00 |
Price Per Unit | $3.27 / millilitre | $29.60 / Ounce | $26.00 / Fl Oz | $28.95 / Fl Oz | $13.67 / Fl Oz | $88.06 / Fl Oz |
Delivery | Get it as soon as Thursday, Mar 6 | Get it as soon as Thursday, Mar 6 | Get it as soon as Thursday, Mar 6 | Get it as soon as Thursday, Mar 6 | Get it as soon as Thursday, Mar 6 | Get it as soon as Thursday, Mar 6 |
Customer Ratings | ||||||
Sold By | Biotulin USA | LG Household Official | Beauty Glow USA | NANO RECIPE | numbuzin Official | Paula's Choice Skincare |
skin type | All | All | All | All | All | Oily, Combination, Dry, Normal, Acne Prone |
active ingredients | spilanthol | hyaluronic acid | Organic Spilanthes Acmella Oleracea (Paracress Flower) Infused & MCT Oil | Volufiline 100% | — | — |
form | Gel | SERUM | Oil | liquid | Drop | Gel |
volume | 15 milliliters | 35 milliliters | 1 fluid ounces | 0.01 cubic inches | — | 20 milliliters |
Important information
Safety Information
Do not use if you have compositae allergy (paracress).
Ingredients
AQUA/WATER, GLYCERIN, BUTYLENE GLYCOL, ALCOHOL, IMPERATA CYLINDRICA ROOT EXTRACT, ACMELLA OLERACEA EXTRACT, XANTHAN GUM, CARRAGEENAN, BENZOIC ACID, PHENOXYETHANOL, VITIS VINIFERA (GRAPE) LEAF EXTRACT, SODIUM HYALURONATE, SODIUM HYDROXIDE, CARBOMER, CAPRYLYL GLYCOL, ACRYLATES / C10-30 ALKYL ACRYLATE CROSSPOLYMER, ETHYLHEXYLGLYCERIN, DEHYDROACETIC ACID.
Looking for specific info?
Customer reviews
Customer Reviews, including Product Star Ratings help customers to learn more about the product and decide whether it is the right product for them.
To calculate the overall star rating and percentage breakdown by star, we don’t use a simple average. Instead, our system considers things like how recent a review is and if the reviewer bought the item on Amazon. It also analyzed reviews to verify trustworthiness.
Learn more how customers reviews work on AmazonCustomers say
Customers find that the skin serum improves its texture and tightens it. They mention that it looks dewy without being greasy, and helps smooth out wrinkles. However, some feel that it's not worth the money. There are mixed opinions on its functionality, moisturizing properties, and effectiveness.
AI-generated from the text of customer reviews
Customers like the skin texture. They say it looks better, dewy without being greasy, smoother, and flatter. Many appreciate the gel texture that feels comfortable and well-presented. However, some find their skin doesn't feel soft after using the product.
"My aunt from Germany was in town she is 76. Her skin looked flawless and so young. She turned me on to this product ...." Read more
"...It plumped everything out within MINUTES, and my skin looked dewy without being greasy...." Read more
"...The packaging also looks very elegant and the price is extremely reasonable (actually much cheaper than the usual skin care products I used to buy)...." Read more
"...I see no results at all, and it actually irritates my skin. I realize that everyone’s body chemistry is different, but I was hopeful." Read more
Customers like the tightening effect of the serum. They say it feels nice on their face and helps tighten under the eyes.
"...Once you apply it it feels like your skin gets tightened. I love this feeling! Apart from that some wrinkles get less for some hours...." Read more
"It feels nice but did absolutely nothing!" Read more
"Seems to tighten the skin" Read more
"...I do but this serum helps tighten with a Loreal blur cream under light makeup. I do have age spots but alittle It concealer helps cover those...." Read more
Customers are satisfied with the product's wrinkle-reducing effects. They say it helps reduce deep wrinkles and makes their skin look younger and smoother.
"...After that that period some off the smaller wrinkles were less or disappeared and my skin was feeling really smooth...." Read more
"...When I'm not grinning like a good ball, there are hardly any wrinkles! (I'm almost 64 yrs old)...." Read more
"...to admit that I'm pleasantly surprised to notice how my wrinkles have improved a great deal only after using it a few days...." Read more
"...I use a microneedler before application and my skin looks younger and smoother. I still have slight forehead lines and crows feet but not as bad...." Read more
Customers like the gel consistency of the skin serum. They say it feels nice on their face, but it doesn't do anything to make their neck look firmer. They appreciate the texture and feel the strength of the topical anesthetic.
"...I wanted to try alternatives for fun. You can definitely feel the strength topical anesthetic!..." Read more
"...face looks good even has helped with my goose neck seems to make it look firmer. Will definitely buy again even for price!" Read more
"...Try it!! My skin is sensative & no problems so far. No odor. Consistency is a clear gel. Drys quickly. No mess or smell. I am hooked." Read more
"...It has a gel consistency, feels nice on your face, but it doesn't do what it's supposed to do. Save your money." Read more
Customers have mixed opinions about the product's functionality. Some find it works well and is worth the price. Others report no results or irritation after using it multiple times.
"Seems great, time will tell!" Read more
"Expensive product that produces no results." Read more
"Excellent product. I would highly recommend it. Best with consistent use." Read more
"...results I will keep enjoying over time, but this honestly is working for me so well that I won't be racing back to my med spa." Read more
Customers have different experiences with the skin serum's moisturizing effects. Some find it amazing and effective, leaving their skin feeling smooth and reducing wrinkles. Others report that it lacks moisture and causes dryness and irritation.
"...off the smaller wrinkles were less or disappeared and my skin was feeling really smooth. So in short , I am happy with this product." Read more
"I t didn’t work as well as advertised; not as moisturizing as advertised. I used it 5x only" Read more
"...I am 73 years young and this product helps smooth my skin. I also use retinol serum at night and Olay regenerist (red jar) am & pm...." Read more
"...this is the first skin care product where I can notice a visible difference on my skin...." Read more
Customers have different experiences with the product's ability to reduce fine lines. Some find it smooths and diminishes the visibility of fine lines after using it. However, others report no change in fine lines or light wrinkles.
"...My wrinkles around the eyes and my forehead are noticeable smoother and flatter...." Read more
"...So far, it does not reduce fine lines, as in the ad. Been using for a week, and notice no difference after application." Read more
"This product is advertised as being able to help with the reduction of fine lines, which is what I want...." Read more
"This was absolutely not worth the money. I noticed zero difference in the lines on my face and in the firmness of my skin...." Read more
Customers are dissatisfied with the product's value for money. They find it overpriced and lacking in effectiveness. The serum seems to have little content, leading to disappointment.
"...She turned me on to this product . A bit pricey but a little goes a long way. I am 55 and I only use in the morning...." Read more
"Expensive product that produces no results." Read more
"...A little expensive. But use it sparingly It works." Read more
"...The packaging also looks very elegant and the price is extremely reasonable (actually much cheaper than the usual skin care products I used to buy)...." Read more
Reviews with images
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Great Value!
Top reviews from the United States
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- Reviewed in the United States on February 19, 2018Normally i don't write reviews but I would like to share my opinion on that. I am working in the cosmetics industry since more than 15 years. I run a cosmetic shop and treatments on my one. During the years a lot of brands come and go and being a professional you get a feeling for good quality products or marketing bluffs quite easily. One of my customers recommended me this product and i tried it out some weeks ago.
Normally my skin gets quite easily irritated, but not with this product. Once you apply it it feels like your skin gets tightened. I love this feeling! Apart from that some wrinkles get less for some hours. I would say in the beginning you will have a tighter skin and less wrinkles fro some hours but the real affect happened to me after using it daily for about three weeks. After that that period some off the smaller wrinkles were less or disappeared and my skin was feeling really smooth.
So in short , I am happy with this product.
- Reviewed in the United States on September 21, 2024My aunt from Germany was in town she is 76. Her skin looked flawless and so young. She turned me on to this product . A bit pricey but a little goes a long way. I am 55 and I only use in the morning. Put it on let is sit for a minute and then do my regular routine. I have gotten lots of compliments on my skin since using it . I didn’t notice as much as others did
- Reviewed in the United States on October 6, 2024Expensive product that produces no results.
- Reviewed in the United States on February 9, 2025It works! Couldn’t believe that the lines around my mouth were significantly gone after only an hour! With continuous use, I am seeing them all continue to fade as well as on other areas of my face.
- Reviewed in the United States on February 20, 2022i will continue to use to see if notice any difference. So far, it does not reduce fine lines, as in the ad. Been using for a week, and notice no difference after application.
- Reviewed in the United States on July 26, 2022As having been a former esthetitian, I can't recommend this product enough! I am not one to leave reviews, ESPECIALLY after the first application of a product. I always advise to wait 3 months when it comes to skincare product reviews and results. I had skeptical low expectations, but thought it would be fun to try after forgetting to bring along SPF on a trip. I just tried it for the first time, and I am VERY impressed. I am a 32 yr. Old female beginning to show minimal signs of aging. I'm not opposed to to botox injections, but feel that it's too soon to commit. I wanted to try alternatives for fun. You can definitely feel the strength topical anesthetic! I suffer from horrible sinus and hormonal headaches, and this most definitely took the edge off (NOT eliminated). It plumped everything out within MINUTES, and my skin looked dewy without being greasy. From a professional standpoint, I tend to think the amount of time to see DRASTIC improvement will depend on the amount of aging, and/or damage done to skin. I would highly recommend for anyone in my position that is on the fence about going under the needle! I'm all for aging naturally for as long as I possibly can 😆. Just keep in mind not to jump to conclusions until you've used the product for around 3 months (without any adverse reactions). I hope this review helps!
- Reviewed in the United States on December 9, 2024It feels nice but did absolutely nothing!
- Reviewed in the United States on January 14, 2025Excellent
Top reviews from other countries
- JuliReviewed in Canada on August 11, 2024
5.0 out of 5 stars Biotulin Supreme Skin Gel
Saw a noticeable difference in my facial lines within several days and now after 2 weeks it’s been amazing. Will continue to use this product.
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RicardoReviewed in Mexico on April 11, 2023
2.0 out of 5 stars no funciona como lo promocionan
en la publicidad que hacen marcan un antes y un después de su aplicación, en mi caso no vi algún cambio en un mes de usarlo
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AmnesiaReviewed in France on November 29, 2024
5.0 out of 5 stars Biorulin sérum
Sérum hydratant et liftant je confirme une nette amélioration de peau.
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BabouReviewed in Belgium on November 26, 2024
4.0 out of 5 stars On ne peut pas être et avoir été
Pour le moment pas de résultat mais les miracles n'existent pas
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AinoaReviewed in Spain on November 25, 2024
5.0 out of 5 stars Efectivamente reduce surco nasogeniano y frente
Si reduce arrugas
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