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Body

OS-01 BODY Topical Supplement

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  • Suited to All skin types, safe for sensitive skin
  • Format Nourishing moisturizer
  • Targets Crepiness, dehydration, skin barrier function

OS-01 BODY is a restorative skin longevity treatment powered by the OS-01 Senescence Blocking Peptide™, designed to strengthen the skin barrier, improve hydration, and promote firm, resilient skin from the neck down.01

OneSkin

BENEFITS

Nourishing body moisturizer and targeted treatment for thin, crepey skin

Smooth texture

Improves the root cause of crepey skin by supporting epidermal thickness for a firmer look and feel.01

Deep hydration

Replenishes and locks in hydration to keep skin soft, plump, and nourished.01

Barrier support

Fortifies the skin barrier to protect against daily stressors and moisture loss.01

5-STAR REVIEWS

See why customers love OS-01 BODY

“The skin on my legs was starting to look older, dry and crepey at 46. Now it is plump and youthful like it was 10 years ago after only a few weeks.” – Jen A.

"The One skin, OS-O1 Body, has been a game changer, within a few weeks I saw a remarkable difference in the quality of my skin, and my skin's appearance continues to improve with daily application. It now has a tighter, less dry look and the texture has almost returned to my premenopause condition..more moist and fresh in appearance. Science is everything, and One Skin has got the science spot on." – Tia T.


"I love this body lotion. My crepey skin is transforming. I wish I had taken pictures before I started using it but I have tried so many different products with no results that I didn’t have much confidence that this one would be any different. Boy was I wrong. I’m hoping that it will eventually get rid of all my dark spots on my skin. I will be a forever customer..."– Myra P.

CLINICAL DATA

Visible results, scientifically validated

93

of participants reported improved hydration 01

72

of participants reported improved appearance 01

70

of participants reported improved texture 01

41

Improvement in skin barrier function was measured 01

The Science Behind OS-01 BODY

Your skin is your largest organ and plays a vital role in your overall health as you age. Over time, it becomes thinner, more fragile, and less effective at protecting you from external aggressors. While most skincare focuses on the face, the other 97% of your skin is just as essential for longevity and well-being. OS-01 BODY is designed to strengthen your skin barrier from the neck down, keeping it resilient.

To evaluate OS-01 BODY’s effectiveness, our scientists measured epidermal thickness—a key indicator of barrier strength—using human skin samples in the lab. Results showed a 40% increase in epidermal thickness compared to untreated skin. This aligns with clinical findings demonstrating OS-01 BODY enhances skin barrier function by up to 41.49%.01


Shown in lab studies on ex vivo human skin samples by measuring epidermal thickness of histology images. Skin treated with OS-01 BODY displayed a significant average increase of +40% compared to skin with no treatment. Data was measured in triplicate.

Getting started with OS-01 BODY

Follow these easy steps for optimal results

  • Apply to arms, legs, chest, back, and stomach
  • Massage until absorbed
  • Use 2 times daily

How it works

Powered by the OS-01 Senescence Peptide™

The first and only peptide scientifically proven to reverse skin’s biological age.02,03

All Ingredients

Water, Glycerin, Limnanthes Alba (Meadowfoam) Seed Oil, Sorbitan Olivate, Avena Sativa (Oat) Kernel Oil, Squalane, Prunus Domestica Seed Oil, Saccharide Isomerate, Cetearyl Olivate, d-Panthenol, Mangifera Indica (Mango) Seed Butter, Tremella Fuciformis (Mushroom) Extract, Tocopheryl acetate, Decapeptide-52*, Allantoin, Asiaticoside, Centella Asiatica Extract, Sodium Hyaluronate Crosspolymer, Ceramide NP, Anadenanthera Colubrina Bark Extract, Lepidium Sativum Sprout Extract, Genistein, Niacinamide, Glycerol, Bentonite, Cetyl Palmitate, Sorbitan Palmitate, Lecithin, Xanthan Gum, Polyglyceryl-10 Laurate, Polyglyceryl-6 Oleate, Sorbitan Oleate, Glyceryl Caprylate, Polysorbate 80, Alcohol, Caprylyl Glycol, Sorbic Acid, Citric Acid, Sodium Citrate, Pentylene Glycol, Potassium Sorbate, Ethylhexylglycerin, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Phenoxyethanol. *OS-01 Peptide

Citations

01Based on data from clinical studies and/or lab studies conducted on human skin samples, 3D skin models, and skin or hair cells in the OneSkin lab. Explore more at oneskin.co/claims

02Zonari, A., et al. Senotherapeutic peptide treatment reduces biological age   and senescence burden in human skin models. npj Aging, 9(1), 1-15. 2023. doi:10.1038/s41514-023-00109-1

03Boroni, M. et al. Highly accurate skin-specific methylome analysis algorithm as a platform to screen and validate therapeutics for healthy aging. Clinical Epigenetics 12, 105. 2020. doi:10.1186/s13148-020-00899-1

OS-01 BODY Topical Supplement

4.7
Rated 4.7 out of 5 stars
Based on 2,439 reviews
Total 5 star reviews: 1.9k Total 4 star reviews: 336 Total 3 star reviews: 108 Total 2 star reviews: 27 Total 1 star reviews: 34
93%would recommend these products
2,439 reviews
  • D
    Danielle
    I recommend this product
    Rated 5 out of 5 stars
    2 days ago
    5 Stars

    Amazing texture.

  • LM
    Laurie M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    2 days ago
    Os-01 Body-impressed so far

    Started using the os-01 body lotion about 3 weeks ago, have tried many “crepe erase” creams in the past, with consistent twice daily use, this formulation far exceeds anything else I’ve tried!

  • CS Profile picture for Charell Smith S.
    Charell Smith S.
    Verified Buyer
    Reviewing
    OS-01 BODY
    I recommend this product
    Rated 5 out of 5 stars
    3 days ago
    Soft as a baby

    I have always been on top of moisturizing my skin from top to bottom. I have used a very good natural product for years and was not necessarily planning to change. However, I am turning 60 this year and was feeling the need to step my moisturizing routine. The fact that OneSkin has developed the OS-01 peptide scientifically formulated to improve skin resilience, boost hydration, and strengthen the epidermal barrier was very appealing to me. I’ve been using OneSkin for about two months. I really love how soft it makes my skin feel without being heavy or sticky. I love the fact that the scent is almost non-existent so as not to compete with my perfume. It’s worth every penny LOVE, LOVE, LOVE!

    OneSkin
    2 days ago

    Hi Charell!

    Thank you for the review! We are happy to hear you are enjoying OS-01 BODY!

  • JS
    Jennifer S.
    Verified Buyer
    Reviewing
    OS-01 BODY
    I recommend this product
    Rated 5 out of 5 stars
    3 days ago
    Love this lotion

    I've noticed an improvement in my skin texture since using this. I also love that it has no fragrance and is not greasy or heavy

  • CM
    Christine M.
    Verified Buyer
    Reviewing
    OS-01 BODY
    I recommend this product
    Rated 5 out of 5 stars
    3 days ago
    Amazingggg!

    I listened to a podcast, Catt Sadler Now and she raved about this product. I decided I had to try it for myself to reverse creepy skin. It truly reverse the aging of my skin! I loved it so much that I went on to buy the entire skin care line including the face wash, the eye cream and the face cream! Overall it’s been a game changer for me and on a consistent daily basis I get comments and how amazing my skin looks!

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