Cell Forté Serum | Exosomes

Shake well. Apply a dropper of Cell Forte Serum on your fingertips, then immediately apply to cleansed, dry face and neck in the morning and evening. You may use other products afterward as part of your everyday routine. If using Elderberry Bakuchiol Serum or other exfoliant in your routine, cut back to two to three times per week.

FOR BEST RESULTS, Angela recommends applying in the morning and evening. Each bottle should last approximately 30 days with twice daily use.

This serum reduces the appearance of fine lines and wrinkles and improves the brightness and radiance of your skin within four weeks without disrupting the skin’s natural barrier. The result is younger-acting skin, significantly enhanced brightness and clarity, and smoother texture and tone.

1 fl. oz.

RESULTS from twice daily use of Cell Forte Serum, am and pm, after a 28-day perception study with 39 women aged 40-60.

91% agreed it helped reduce the look of hyperpigmentation
90% said skin looks more youthful
87% said skin increases luminosity
85% said skin elasticity improved
85% said it fades the look of fine lines and wrinkles

Scientific and Clinical Studies:

A growing body of peer-reviewed research and clinical trials has evaluated the efficacy of ADMSC conditioned media in skincare. Below is a summary of notable studies:

• Kim et al., 2020 (Biomedical Dermatology): In one of the first direct clinical trials, 60 middle-aged women with hyperpigmentation and wrinkles were divided into three groups (20 each) to test a cosmetic containing human ADMSC-CM[13][14]. For 28 days, Group E1 applied a cream with 5% ADMSC-CM twice daily; Group E2 used a cream with 5% ADMSC-CM encapsulated in polymersomes (to enhance delivery); Group C was placebo. The results were significant: skin moisture content increased, transepidermal water loss (TEWL) decreased, and pigmentation and wrinkle depth improved in the ADMSC-CM groups compared to control[15][16]. Group E1 (plain ADSC-CM) showed markedly better skin hydration and reduced melanin/erythema than placebo, and Group E2 (encapsulated form) showed the greatest improvements in all measured parameters – including moisture, barrier function, pigmentation (melanin index), redness, wrinkle size, and skin roughness. This study not only confirmed ADMSC-CM’s effectiveness in human topical use but also highlighted that advanced delivery systems (polymersomes) can further enhance results[19]. No adverse reactions were reported, and a follow-up of this trial is expected to solidify these findings[20].

• Lee et al., 2021 (J. Cosmet. Dermatol.): This randomized controlled trial assessed ADMSC-CM in a post-laser anti-aging regimen. Twenty-five patients with aging skin underwent fractional ablative laser on the face, then for 3 weeks applied a moisturizer with 2% niacinamide with or without ADMSC-CM to opposite sides of the face[21]. The side treated with the ADMSC-CM+niacinamide showed significantly greater improvements: wrinkle index and hyperpigmentation (melanin index) were reduced more than the control side[22][6]. Patients also rated higher satisfaction and global aesthetic improvement on the ADMSC-CM side[6]. Importantly, laboratory analyses revealed why: skin samples from the ADMSC-CM side had lower pro-inflammatory cytokines, lower MMP-1/MMP-2 (collagen-degrading enzymes), and higher type I collagen expression[6]. This indicates that ADMSC-CM helped suppress inflammation and protect the skin’s collagen post-injury. The authors concluded that topical ADSC-conditioned media significantly enhances skin rejuvenation after laser therapy, with no notable side effects beyond what the laser itself caused[6].

• Ahn et al., 2023 (Annals of Dermatology): Although this study used conditioned media from umbilical cord MSCs rather than adipose, it provides relevant evidence for MSC-CM’s benefits on sensitive, barrier-damaged skin. In a split-face trial, 27 patients had a nonablative laser applied to induce a controlled skin barrier disruption, then applied UCB-MSC conditioned media to one side vs. saline to the other. The MSC-CM–treated side showed significantly better barrier recovery – lower TEWL and less redness – and patients reported less irritation[25]. The authors noted that MSC-CM treatment improved skin barrier function and reduced inflammatory responsiveness, suggesting benefits for sensitive or rosacea-prone skin[26]. By analogy, ADMSC-CM (which shares many growth factors with UCB-MSC-CM) likely confers similar barrier-strengthening and calming effects.

https://biomeddermatol.biomedcentral.com/articles/10.1186/s41702-020-0056-9#:~:text=Results

https://pubmed.ncbi.nlm.nih.gov/33103316/#:~:text=derived%20stem%20cell,controlled%20study

https://pubmed.ncbi.nlm.nih.gov/26735291/#:~:text=...%20pubmed.ncbi.nlm.nih.gov%20%20ADSC,acne%20scars%20and%20skin%20rejuvenation

https://anndermatol.org/DOIx.php?id=10.5021/ad.21.287#:~:text=The%20treated%20side%20exhibited%20greater,was%20significantly%20improved%20after%20treatment

https://www.dovepress.com/adipose-derived-stem-cell-products-and-combination-therapies-for-the-t-peer-reviewed-fulltext-article-CCID#:~:text=Adipose,DCN%29%2C%20a%20small

https://www.frontiersin.org/journals/medicine/articles/10.3389/fmed.2022.858824/full

Human Adipose Mesenchymal Stem Cell (MSC) Conditioned Media:

Conditioned media is a powerful byproduct generated when human stem cells are cultured and nurtured in a controlled environment. During this process, stem cells release powerful growth factors, cytokines, and proteins that hold the key to skin rejuvenation.

BIOMSC™️:

Proprietary blend of our protein-rich human-derived 'conditioned media' and a combination of synthetic peptides and hydrators.

Tremella Fuciformis Sporocarp Extract:

Clinically proven to be 10x more hydrating than hyaluronic acid.

Lipid Lock Technology™️:

Proprietary bio-identical natural delivery system.

Bacillus Ferment Extract:

Probiotic maintains a healthy skin microbiome, balanced pH, and strengthens the skin barrier.

Hyaluronic Acid:

Different molecular weights for extra hydration.

FULL INGREDIENT LIST:

Water (Aqua), Propanediol, Human Adipose-Derived Stem Cell Conditioned Media, sh-Oligopeptide-1, sh-Oligopeptide-2, sh-Polypeptide-1, sh-Polypeptide-9, sh-Polypeptide-11, Acetyl Glutamine, Alanine, Allantoin, Arginine, Bacillus Ferment, Bacillus/Folic Acid Ferment Filtrate extract, Betaine, Bisabolol, Citric Acid, Glutamic Acid, Glycerin, Glycine, Hydrolyzed Eragrostis Tef Seed Extract, Hydrolyzed Eragrostis Tef Seed Extract, Hydrolyzed Hyaluronic Acid, Lecithin, Limnanthes Alba (Meadowfoam) Seed Oil, Lysine HCl, Niacinamide, Panthenol, PCA, Proline, Pullulan, Serine, Sodium Hyaluronate, Sodium Lactate, Sodium PCA, Threonine, Tremella Fuciformis Sporocarp Extract, Xanthan Gum, Sclerotium Gum, Caprylyl Glycol, Ethylhexylglycerin, 1,2-Hexanediol, Trisodium Ethylenediamine Disuccinate, Sodium Benzoate

BENEFITS:

*Reduces the appearance of sun damage
*Improves the appearance of fine lines and wrinkles
*Reduces the look of hyperpigmentation
*Improves the look and feel of the skin

FEATURES:

*Suitable for all skin types
*8 in 1 product
*Fragrance- and dye-free
*Cruelty-free
*Clean, allergen-free formulation
*Multi-level hydration
*Luxurious silky, highly absorbable texture
*Human MSC conditioned media is produced in a cGMP laboratory
*Small-batched produced